Discover projects
The Science

Sweat

the details.


Sweat contains a broad range of critical biomarkers that can help you unlock your performance potential. For the first time ever, LIMINA will be able to detect Hypoxanthine in real-time, the unique metabolite that is a key indicator of muscular degradation.

How It Works

Backed by research.

Hypoxanthine as a predictor of performance in highly trained athletes

2013. Abstract: In summary, hypoxanthine is a strong predictor of performance in highly trained athletes and its prediction ability is very high regardless of sport specialization, spanning the continuum from speed-power to endurance disciplines.t's hypoxanthine levels to drive your workout for optimal intensity, performance & recovery

Hypoxanthine: A Universal Metabolic Indicator of Training Status in Competitive Sports

2015. Abstract: According to some recent studies, purine metabolism better reflects exercise response and muscle adaptation in this group. We propose using purine derivatives, especially plasma hypoxanthine concentration, as indicators of training status in consecutive training phases in highly trained athletes.

Training-induced adaptation in purine metabolism in high-level sprinters vs. triathletes

2012. Abstract: The changes in plasma Hx concentration and erythrocyte HGPRT activity may provide information about the energetic status of the muscles in highly trained athletes in which no significant adaptation changes are detected by means of commonly acknowledged biochemical and physiological parameters.

The basics

Hypoxanthine 101
At the most basic level, workouts need energy and as you are working out, the body is looking for that energy in the form of ATP. Carbs, Fats & Proteins are the body’s fuel and are converted to ATP when the body needs this energy.

Now, ATP is created either aerobically or anaerobically, depending on the workout. In aerobic workouts (think endurance running, long distance cycling etc), the body is able to create large amounts of ATP via oxygen reacting with fats and glucose and keep producing it for extended periods of time. As long as there is a continual supply of fuel (eg. fats and carbohydrates stored in the body) and oxygen, aerobic activities can continue for long periods. Eventually, however, your body can’t absorb oxygen at the same rate and it flips into the anaerobic energy system. The lack of oxygen activates specific enzymes that drive ATP breakdown products into IMP, and further into hypoxanthine, xanthine and uric acid. Hypoxanthine is the last step before ATP degradation reaches the "point-of-no return."

In anaerobic workouts (sprinting, baseball, soccer, weightlifting etc), the body requires a large amount of energy quickly and will not have sufficient oxygen to create a large amount of ATP. It will require glucose to access ATP. The anaerobic processes cannot continue indefinitely as the stores of ATP become depleted Again, The lack of oxygen activates specific enzymes that drive ATP breakdown products into IMP, and further into hypoxanthine, xanthine and uric acid. Hypoxanthine is the last step before ATP degradation reaches the "point-of-no return."
Once ATP degradation has reached Hypoxanthine there are 3 pathways it can go: 1) exit the body through sweat, 2) enter the blood stream (This and only this pathway leads down to xanthine and then uric acid) OR 3) recycled back into IMP (which can be further recycled into ATP) via an enzyme called HGPRT. Research strongly suggest that  well trained individuals can effectively salvage hypoxanthine due to muscle  adaptation.  As individual become more fit, their bodies produce more HGPRT and they will expel less Hypoxanthine into sweat and blood. Therefore, tracking Hypoxanthine is a great way to monitor exercise and fitness, as it allows us to for the first time see how our own biochemistry is improving and becoming more efficient (i.e. body recycles energy use better) as we improve our own health and fitness through exercise.
 
Our technology: As we all know, exercise induces sweat. As metabolite rich sweat runs over our patented carbon material, the metabolite signatures are sent to your app in real-time.  For example, if an endurance athlete is overdoing it, our App will show a spike in hypoxanthine. This indicates that the athlete is not recycling ATP (energy) and is going to be headed for a crash and reduced performance. It also means that the athlete will build up uric acid and will need longer to recover before their next workout.